The goal of any imaging methodology used in dermatology is to diagnose melanoma in early stages because it depends on the effectiveness of treatment. Investigations shows, that early diagnosis is more than 90% curable and late is less than 50% . The diagnosis and successful treatment are often supplemented with permanent monitoring of suspicious skin lesions. Doctor’s diagnosis is reliable, but this procedure takes lots of time, efforts. These routines can be automated. It could save lots of doctor’s time and could help to diagnose more accurately. Besides using computerized means there are excellent opportunity to store information with diagnostic information in order to use it for further investigations or creation of new methods of diagnosis. Skin lesion imaging methods We found that there are number of various imaging methods of skin lesions . The simplest skin visualization method is photography. This method gives only top layer skin image. In order to get deeper layer image there is oil immersion used. It reduces reflections of surface and brightens the image of epidermis – the second skin layer.